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Transient severe thrombocytopenia with SARS-Cov-2 (COVID-19) infection in pregnancy

Authors:

I. A. Jayawardane ,

University of Colombo, LK
About I. A.
Department of Obstetrics and Gynaecology, Faculty of Medicine
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I. Piyadigama,

De Soysa Hospital for Women, Kinsey Road, Colombo 8, LK
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H. Solangaarachchi,

Hospital Homagama, LK
About H.
Obstetrics and Gynaecology Unit, Base
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S. Williams

University of Kelaniya, LK
About S.
Department of Pathology, Faculty of Medicine
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Abstract

A 24-weeks pregnant woman in her 2nd pregnancy presented with mild COVID symptoms and new onset rapidly progressive severe thrombocytopenia with a nadir of 20×109/L. She did not have any bleeding manifestations and the platelet counts recovered over 3 days without the need of steroids or immunoglobulin treatment. COVID-19 infection may cause transient severe thrombocytopenia, and this has not been previously reported in second trimester of pregnancy. We speculate the cause to be immune mediated. Other causes for severe thrombocytopenia were excluded after comprehensive investigations. This raise concerns on thromboprophylaxis and anticoagulant use in early pregnancies infected with COVID-19. Assessing the platelet counts at least two occasions few days apart of an infected patient may be a safer approach if continuing anticoagulants.

How to Cite: Jayawardane, I.A., Piyadigama, I., Solangaarachchi, H. and Williams, S., 2021. Transient severe thrombocytopenia with SARS-Cov-2 (COVID-19) infection in pregnancy. Sri Lanka Journal of Obstetrics and Gynaecology, 43(4), pp.322–325. DOI: http://doi.org/10.4038/sljog.v43i4.8028
Published on 30 Dec 2021.
Peer Reviewed

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