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Research Article

Screening for Cytomegalovirus Infection During Pregnancy in a Teaching Hospital, Western province, Sri Lanka

Authors:

J. I. Abeynayake ,

Medical Research Institute, Colombo 08, LK
About J. I.
Consultant Medical Virologist, Virology Department
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M. A. K. Perera,

De Zoysa Hospital for women, Colombo 8, LK
About M. A. K.
Consultant Obstetrician & Gynaecologist
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C. K. Gunasekara,

De Zoysa Maternity hospital, Colombo 8, LK
About C. K.
Senior House Officer
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B. Samaraweera,

Medical Research Institute, Colombo 08, LK
About B.
Medical Virology Registrar, Virology Department
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N. Wickramasinghe

Medical Research Institute, Colombo 08, LK
About N.
Medical Laboratory Technologist, Virology Department
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Abstract

Primary Cytomegalovirus (CMV) infection during pregnancy is a serious threat to the fetus. Although vertical transmission is likely to occur as a result of maternal infection, the rate of permanent sequelae is higher among infants born to mothers with primary CMV infection. Diagnosis of CMV infection among healthy adults generally relies on serological testing as most of them are asymptomatic. CMV infection in pregnancy is barely studied in Sri Lanka. This study aims in screening for CMV infection of selected pregnant population in a major maternity hospital and to describe associated factors with seropositivity. This study included 385 pregnant women in second trimester presented during a period of 6 months. Mothers with immunocompromised states were not recruited. Questionnaire was used to gather sociodemographic and clinical factors. All serum samples were tested for CMVIgG and IgG-avidity assay for seropositives. CMV-IgM test was carried out on samples with negative CMV-IgG and low/equivocal-avidity levels. All 3 seromarkers were tested using commercial Enzyme Linked Immunosorbent Assays. Data were analyzed by SPSS. Majority (97%) of the population were positive for CMV-IgG. CMV-avidity was low, equivocal or high in 0.25%, 2.75% and 97% of IgG seropositives respectively. Age, bad obstetric history and multiparity didn’t show association with IgG seropositivity. In conclusion, CMV seroprevalence was high in this study population with low rates of recent primary infection. Education regarding preventive measures for CMV infection in antenatal care has a value as some proportion were seronegative for CMV with prone to get new infections.
How to Cite: Abeynayake, J.I. et al., (2017). Screening for Cytomegalovirus Infection During Pregnancy in a Teaching Hospital, Western province, Sri Lanka. Sri Lanka Journal of Obstetrics and Gynaecology. 39(4), pp.69–73. DOI: http://doi.org/10.4038/sljog.v39i4.7825
Published on 23 Dec 2017.
Peer Reviewed

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