Objective: To observe the role of indomethacin in polyhydramnios.
Method: This was a prospective, longitudinal and analytical study conducted in Kathmandu University Hospital, Dhulikhel from 1st July 2011 to 1st of December 2012. There were 32 patients included in the study. Indomethacin was administered orally at the dose of 25 mg three times a day for 1 week. The patients were admitted for observation of clinical symptoms, fundal height, fetal status and amniotic fluid index measurement. After the delivery, baby was investigated for any abnormality of fetal circulation.
Results: There were total of 2700 deliveries in 1 year. Among them 46 cases were of polyhydramnios. The frequency was 1.7%. Among the 46 cases, 32 (69.6%) were idiopathic who were included whereas 8 (17.4%) were of diabetes mellitus, 4 (8.7%) were Rh isoimmunisation, and 2 (4.3%) were fetal anomalies. The mean age group was 24.5+/-4.2 years. There were total 10 (31.3%) patients presented at 29 weeks of gestation whereas only 5 (15.7%) patients at 32 weeks of gestation. Regarding the gravid index, 17 (53.1%) patients were primigravida. There was statistically significant reduction in amniotic fluid volume following 1 week administration of indomethacin.
Conclusion: Though there are many modes of treatment for polyhydramnios, the 1 week therapy with indomethacin is equally beneficial.