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Research Article

The effects of levonorgestrel intra-uterine system on adenomyosis and endometriosis: A three year follow up study

Authors:

Pramathes DasMahapatra ,

Spectrum Clinic and Endoscopy Research Institute, Kolkata, IN
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Partha Bhattacharyya,

Spectrum Clinic and Endoscopy Research Institute, Kolkata, IN
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Pritha DasMahapatra

Spectrum Clinic and Endoscopy Research Institute, Kolkata, IN
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Abstract

Objective: To study effects of levonorgestrel intra-uterine system (LNG-IUS) on adenomyosis with and without endometriosis.

Design: Fifty-eight women with a confirmed diagnosis of adenomyosis after exclusion of confounding factors, and detection or exclusion of endometriosis were selected. They were categorized into group A (only adenomyosis, n=44) and group B (adenomyosis plus endometriosis, pre-treated by laparoscopic surgery, n=14) received LNG-IUS between July 2004 and January 2006 and were followed up on five different parameters.

Results: Analysis of three years’ follow up shows mean reduction of different variables in groups A and B as dysmenorrhoea (visual analogue scale) 98.2±3.9% and 98.3±3.7% (p<0.0001) menstrual bleeding (blood-loss assessment chart) 92.2±11.2% and 85.0±17.5% (p<0.0001), chronic pelvic pain (pain-calendar) 98.8±2.7% and 96.4±4.9% (p<0.0001); uterine volume 27.8±9.0% and 28.7±9.6% (p<0.0005) maximum endo-myometrial junctional-zone thickness 30.2±7.9% and 26.0±4.8% (p<0.0005). Effects on groups A and B were comparable. Other observations were – amenorrhoea-27.5%, intermenstrual bleeding-37.3% and expulsion-6.9%.

Conclusion: LNG-IUS is equally effective for long-term conservative management of both adenomyosis alone and with co-existent endometriosis.

Key words: Adenomyosis; endometriosis; conservative treatment; LNG-IUS.

DOI: http://dx.doi.org/10.4038/sljog.v32i2.3976

SLJOG 2010; 32(2): 27-33

How to Cite: DasMahapatra, P., Bhattacharyya, P. & DasMahapatra, P., (2012). The effects of levonorgestrel intra-uterine system on adenomyosis and endometriosis: A three year follow up study. Sri Lanka Journal of Obstetrics and Gynaecology. 32(2), pp.27–33. DOI: http://doi.org/10.4038/sljog.v32i2.3976
Published on 21 Jan 2012.
Peer Reviewed

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