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Research Article

Chromosomal abnormalities in patients with recurrent spontaneous pregnancy loss and sub-fertility

Authors:

Vajira HW Dissanayake ,

Asiri Centre for Genomic and Regenerative Medicine, Asiri Surgical Hospital, Colombo and Human Genetics Unit, Faculty of Medicine, University of Colombo, LK
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AM Maheshi H Athapaththu,

Asiri Centre for Genomic and Regenerative Medicine, Asiri Surgical Hospital, Colombo, LK
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D Jeewani S Opanayake,

Asiri Centre for Genomic and Regenerative Medicine, Asiri Surgical Hospital, Colombo, LK
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Nethra T Hidellage,

Asiri Centre for Genomic and Regenerative Medicine, Asiri Surgical Hospital, Colombo, LK
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Kalpani Wijetunge,

Asiri Centre for Genomic and Regenerative Medicine, Asiri Surgical Hospital, Colombo, LK
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Christeen RJ Pedurupillay

Asiri Centre for Genomic and Regenerative Medicine, Asiri Surgical Hospital, Colombo, LK
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Abstract

Introduction: Chromosomal abnormalities are implicated in the etiology of recurrent spontaneous pregnancy loss and sub-fertility.
Objective: To describe the chromosomal abnormalities detected in a series of patients with recurrent spontaneous pregnancy loss and sub-fertility tested in our laboratory.
Methods: 442 patients including 348 patients (171couples, 6 women) with recurrent spontaneous pregnancy loss (Group A), 58 patients (24 couples, 4 men, 6 women) with sub-fertility (Group B), 36 patients (18 couples) with IUI/ IVF failure (Group C) were karyotyped.
Results: Chromosomal abnormalities were detected in 42 (9.5%). 21 (50%) were male and 21 (50%) were female. These abnormalities include 33 (79%) structural abnormalities, 9 (21%) numerical abnormalities. All those who had numerical abnormalities were mosaics for normal and abnormal cell lines. The rate of abnormalities seen in groups A, B and C were 8.3% [29/348], 10.4% [6/58], and 19.4% [7/36] respectively. There was a significant difference between the chromosomal abnormalities seen in Group C when compared with combined groups A and B (χ2 = 4.5, df=1, p=0.34).
Conclusions: The detection of a chromosomal abnormality in one partner of a couple experiencing recurrent spontaneous pregnancy loss or sub-fertility alters the management of the couple. Therefore such couples should be karyotyped before they are offered assisted reproductive interventions.

Key words: Chromosomal abnormalities; recurrent spontaneous pregnancy loss; sub-fertility.

DOI: 10.4038/sljog.v31i2.1751

Sri Lanka Journal of Obstetrics and Gynaecology 2009; 31: 84-87

DOI: http://doi.org/10.4038/sljog.v31i2.1751
How to Cite: Dissanayake, V.H. et al., (2010). Chromosomal abnormalities in patients with recurrent spontaneous pregnancy loss and sub-fertility. Sri Lanka Journal of Obstetrics and Gynaecology. 31(2), pp.84–87. DOI: http://doi.org/10.4038/sljog.v31i2.1751
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Published on 03 Apr 2010.
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